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Poly(e-caprolactone)-polyglycolide-poly(ethy-lene glycol)monomethyl ether random copolymers were synthesized from epsilon-caprolactone(epsilon-CL),glycolide(GA)and poly(ethylene glycol)monomethyl ether(MPEG)using stan-nous octoate...
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Poly(e-caprolactone)-polyglycolide-poly(ethy-lene glycol)monomethyl ether random copolymers were synthesized from epsilon-caprolactone(epsilon-CL),glycolide(GA)and poly(ethylene glycol)monomethyl ether(MPEG)using stan-nous octoate as catalyst at 160 deg C by bulk polymerization.The copolymers with different composition were synthesized by adjusting the weight ration of reaction mixture.The resultant copolymer with a weight ratio(10:15:75)of MPEG2000,GA,and CL was characterized by IR,~1H NMR,GPC and DSC.The new biodegradable copolymer has potential for medical applications since it is combined with properties of PCL,PGA and MPEG.
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Abstract Chemokine receptors, a diverse group within the seven-transmembrane G protein-coupled receptor superfamily, are frequently overexpressed in malignant tumors. Ligand binding activates multiple downstream signal transductio...
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Abstract Chemokine receptors, a diverse group within the seven-transmembrane G protein-coupled receptor superfamily, are frequently overexpressed in malignant tumors. Ligand binding activates multiple downstream signal transduction cascades that drive tumor growth and metastasis, resulting in poor clinical outcome. These receptors are thus considered promising targets for anti-tumor therapy. This article reviews recent studies on the expression and function of CXC chemokine receptors in various tumor microenvironments and recent developments in cancer therapy using CXC chemokine receptor antagonists.
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Approximately 30% of lymphomas occur outside the lymph nodes, spleen, or bone marrow, and the incidence of extranodal lymphoma has been rising in the past decade. While traditional chemotherapy and radiation therapy can improve su...
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Approximately 30% of lymphomas occur outside the lymph nodes, spleen, or bone marrow, and the incidence of extranodal lymphoma has been rising in the past decade. While traditional chemotherapy and radiation therapy can improve survival outcomes for certain patients, the prognosis for extranodal lymphoma patients remains unsatisfactory. Extranodal lymphomas in different anatomical sites often have distinct cellular origins, pathogenic mechanisms, and clinical manifestations, significantly influencing their diagnosis and treatment. Therefore, it is necessary to provide a comprehensive summary of the pathogenesis, diagnosis, and treatment progress of extranodal lymphoma overall and specifically for different anatomical sites. This review summarizes the current progress in the common key signaling pathways in the development of extranodal lymphomas and intervention therapy. Furthermore, it provides insights into the pathogenesis, diagnosis, and treatment strategies of common extranodal lymphomas, including gastric mucosa-associated lymphoid tissue (MALT) lymphoma, mycosis fungoides (MF), natural killer/T-cell lymphoma (nasal type, NKTCL-NT), and primary central nervous system lymphoma (PCNSL). Additionally, as PCNSL is one of the extranodal lymphomas with the worst prognosis, this review specifically summarizes prognostic indicators and discusses the challenges and opportunities related to its clinical applications. The aim of this review is to assist clinical physicians and researchers in understanding the current status of extranodal lymphomas, enabling them to make informed clinical decisions that contribute to improving patient prognosis.
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Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor. Toll-like...
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Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor. Toll-like receptors (TLRs) act as the first line of defense in the immune system being the detectors of those associated with bacteria, viruses, and danger signals. In the glioma microenvironment, TLRs are expressed on both immune and tumor cells, playing dual roles eliciting antitumoral (innate and adaptive immunity) and protumoral (cell proliferation, migration, invasion, and glioma stem cell maintenance) responses. Up to date, several TLR-targeting therapies have been developed aiming at glioma bulk and stem cells, infiltrating immune cells, the immune checkpoint axis, among others. While some TLR agonists exhibited survival benefit in clinical trials, it attracts more attention when they are involved in combinatorial treatment with radiation, chemotherapy, immune vaccination, and immune checkpoint inhibition in glioma treatment. TLR agonists can be used as immune modulators to enhance the efficacy of other treatment, to avoid dose accumulation, and what brings more interests is that they can potentiate immune checkpoint delayed resistance to PD-1/PD-L1 blockade by upregulating PD-1/PD-L1 overexpression, thus unleash powerful antitumor responses when combined with immune checkpoint inhibitors. Herein, we focus on recent developments and clinical trials exploring TLR-based treatment to provide a picture of the relationship between TLR and glioma and their implications for immunotherapy.
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Tertiary lymphoid structure (TLS), also known as ectopic lymphoid organs, are found in cancer, chronic inflammation, and autoimmune diseases. However, the heterogeneity of TLS in gliomas is unclear. Therefore, it is necessary to i...
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Tertiary lymphoid structure (TLS), also known as ectopic lymphoid organs, are found in cancer, chronic inflammation, and autoimmune diseases. However, the heterogeneity of TLS in gliomas is unclear. Therefore, it is necessary to identify TLS differences and define TLS subtypes. Methods: The TLS gene profile of 697 gliomas from The Cancer Genome Atlas (TCGA) was used for consensus clustering to identify robust clusters, and the reproducibility of the stratification method was assessed in Chinese Glioma Genome Atlas (CGGA) cohort1, CGGA_cohort2, and GSE16011. Analyses of clinical characteristics, immune infiltration, and potential biological functions were performed for each subtype. Results: Three resulting clusters (A, B, and C) were identified based on consensus clustering on the gene expression profile of TLS genes. There was a significant prognostic difference among the clusters, with a shorter survival for C than B and A. In comparison with the A and B subtypes, the C subtype was significantly enriched in primary immunodeficiency, intestinal immune network for lgG production, antigen processing and presentation, natural killer cell-mediated cytotoxicity, complement and coagulation cascades, cytokine-cytokine receptor interaction, leukocyte transendothelial migration, and some immune-related diseases. The levels of 23 immune cell types were higher in the C subtype than in the A and B subtypes. Finally, we developed and validated a riskscore based on TLS subtypes with better performance of prognosis prediction. Conclusions: This study presents a new stratification method according to the TLS gene profile and highlights TLS heterogeneity in gliomas.
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Edible coatings and films (ECF) are employed as matrixes for incorporating antimicrobial nanoparticles (NPs), and then they are applied on the fruits and vegetables to prolong shelf life and enhance storage quality. This paper pro...
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Edible coatings and films (ECF) are employed as matrixes for incorporating antimicrobial nanoparticles (NPs), and then they are applied on the fruits and vegetables to prolong shelf life and enhance storage quality. This paper provides a comprehensive review on the preparation, antimicrobial properties and mechanisms, surface and physical qualities of ECF containing antimicrobial NPs, and its efficient application to vegetables and fruits as well. Following an introduction on the properties of the main edible coating materials, the preparation technologies of ECF with NPs are summarized. The antimicrobial activity of ECF with NPs against the tested microorganism was observed by many researchers. This might be mainly due to the electrostatic interaction between the cationic polymer or free metal ions and the charged cell membrane, the photocatalytic reaction of NPs, the detachment of free metal ion, and partly due to the antimicrobial activity of edible materials. Moreover, their physical, mechanical and releasing properties are discussed in detail, which might be influenced by the concentration of NPs. The preservation potential on the quality of fruits and vegetables indicates that various ECF with NPs might be used as the ideal materials for food application. Following the introduction on these characteristics, an attempt is made to predict future trends in this field.
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Purpose - The purpose of this paper is to explore the role of communities of practice (CoPs) in facilitating knowledge sharing within a Chinese management consulting company. Design/methodology/approach - A qualitative case study ...
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Purpose - The purpose of this paper is to explore the role of communities of practice (CoPs) in facilitating knowledge sharing within a Chinese management consulting company. Design/methodology/approach - A qualitative case study was conducted within a Chinese management consulting company. Data collection was based on focus group interviews and in-depth interviews. Findings - The finding of this study suggests that there are some knowledge sharing barriers caused by both organizational factors and cultural factors. CoP in the case company have been playing very positive roles in overcoming those barriers and facilitating knowledge sharing in the company. Research limitations/implications - The findings are restricted to the specific context of this study. However, qualitative methodology contributes to thick and rich data and it gives an understanding of the phenomena under study within the context of the study. Therefore, readers can decide and make their own generalizations with relevant context. Practical implications - Based on the research findings, the study developed the knowledge sharing model in the case company, which provides a synthesis for this study result. This model can help related academics and practitioners to understand the Chinese cultural and social influences on knowledge management practice, as well as the role of CoPs in facilitating knowledge sharing in Chinese organisations. Originality/value - Few studies have explicitly paid attention to knowledge sharing within Chinese organizations. This paper provides useful information both for academics interested in cultural issues within knowledge management and impartial advice for knowledge managers within Chinese companies.
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Identifying the main sources of conflict and understanding the relationships between protected areas and local communities are critical to conflict resolution related to protected area management. We surveyed and assessed the perc...
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Identifying the main sources of conflict and understanding the relationships between protected areas and local communities are critical to conflict resolution related to protected area management. We surveyed and assessed the perceptions of local people related to forest values of the Bulong Nature Reserve (BNR), Yunnan, China, and their attitudes toward forest management of the recently-established nature reserve. Factors influencing the differences in perceptions and attitudes were investigated. Our results indicated local residents preferred the economic value of forests, and they perceived more forest values after reserve establishment than before, especially for ecological services. Interviewees believed the value of the forests have increased, and predicted that the forest will have increased importance to their livelihoods and health in the future. Nonetheless, the majority of interviewees were dissatisfied with current reserve management. Variation in these perceptions and attitudes were related to several social variables: age, gender, education, and distance from the reserve. Embedding the findings of the present study, specifically the perceptions and attitudes of local people, into management guidelines for mitigation of potential conflicts is proposed and should help managers to achieve biodiversity-related goals. This study offers new insights related to the identification of the underlying sources of conflict in forest management and provides a better understanding of the relationship between local people and protected areas. The study also contributes to the literature on forest values of indigenous populations by examining those of remote, rural populations in China.
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Stable aerial flight capability is crucial for amphibious vehicles to perform cross-domain motion, yet it is often influenced by unpredictable cross-domain environments and model uncertainties. A fractional-order active disturbanc...
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Stable aerial flight capability is crucial for amphibious vehicles to perform cross-domain motion, yet it is often influenced by unpredictable cross-domain environments and model uncertainties. A fractional-order active disturbance rejection controller based on finite-time convergent extended state observer is proposed for the anti-interference control problem in the attitude trajectory tracking of bullet-shaped trans-domain amphibious vehicle in complex environments. Firstly, a complete dynamic model of the airborne flight system of the bullet-shaped trans-domain amphibious vehicle is established. A hierarchical control scheme based on the proposed controller is designed assuming that all states of the system are available, in order to improve the control reliability and robustness of the flight system in multi-source interference environments. Then, based on a novel hybrid particle swarm search technique called the Particle Swarm Optimization with Levy Flight and Wavelet Mutation algorithm, which combines Levy flight and wavelet mutation, a new parameter identification and tuning algorithm is proposed for the proposed controller to obtain optimal control parameters for attitude and position. To provide a comprehensive comparison, the stability of the optimization algorithm and the robustness performance of the controller were evaluated. Finally, all controllers were tested under three different disturbance scenarios. The results show that the proposed controller can achieve better stability in flight attitude and trajectory tracking tasks compared to Proportion Integration Differentiation controller, Fractional-order Proportion Integration Differentiation controller, and Active Disturbance Rejection controller in all scenarios.
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Transcriptome differences between Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), which are all derived from B cell, remained unclear. This study aimed to construct lymphoma-specific...
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Transcriptome differences between Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), which are all derived from B cell, remained unclear. This study aimed to construct lymphoma-specific diagnostic models by screening lymphoma marker genes. Transcriptome data of HL, DLBCL, and MCL were obtained from public databases. Lymphoma marker genes were screened by comparing cases and controls as well as the intergroup differences among lymphomas. A total of 9 HL marker genes, 7 DLBCL marker genes, and 4 MCL marker genes were screened in this study. Most HL marker genes were upregulated, whereas DLBCL and MCL marker genes were downregulated compared to controls. The optimal HL-specific diagnostic model contains one marker gene (MYH2) with an AUC of 0.901. The optimal DLBCL-specific diagnostic model contains 7 marker genes (LIPF, CCDC144B, PRO2964, PHF1, SFTPA2, NTS, and HP) with an AUC of 0.951. The optimal MCL-specific diagnostic model contains 3 marker genes (IGLV3-19, IGKV4-1, and PRB3) with an AUC of 0.843. The present study reveals the transcriptome data-based differences between HL, DLBCL, and MCL, when combined with other clinical markers, may help the clinical diagnosis and prognosis.
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